Best Formula for Babies with Reflux in 2018 Nov.

Updated by Zoey Miller and verified by the Research Team. Last updated on Aug 28, 2018.

Parents of babies with reflux know all too well how tiring the search for the right formula can be. With so many options, and grand claims by manufacturers, we’ve decided to formulate a list of the five best formulas for babies with reflux, and save you some time and frustration.

5 Best Formula for Babies with Reflux




My Rating


Enfamil Nutramigen Infant Formula with Enflora LGG


Enfamil PREMIUM Gentlease, Milk-Based Formula


Gerber Good Start Gentle Non-GMO Powder Infant Formula


Similac Sensitive Non-GMO Baby Formula


Parent's Choice Gentle Infant Formula

Where to Begin

With so many options in today’s market, the search for the right formula can be exhausting. Parents are faced with the daunting task of choosing between hypoallergenic and “gentle,” non-dairy and low-iron, brand name and generic, and the list goes on. Other options include medical intervention, with tests, procedures, and medications, as well as active engagement from parents, like changing feeding habits, schedules, and positioning. We all know brands can be deceiving in their claims, and advice from doctors, friends, and strangers on the internet can be conflicting, adding to the frustration of it all. To help ease some stress, we’ve boiled down that list to the key factors, and described what each one really means below.


Hypoallergenic formulas are created for infants whose bodies have negative or allergic reactions to certain food proteins, often a cow’s milk protein allergy. In order to claim hypoallergenic properties, formulas must undergo extensive pre-clinical and clinical trials, ensuring that the formula does not induce symptoms in 90% of infants in the study (Source). Your child should react positively to these formulas if the main cause of their reflux symptoms is a protein allergy.


A common belief exists that iron in formulas can cause digestion issues in infants. However, according to the American Academy of Pediatrics, the level of iron in baby formulas can be a major factor in determining whether or not a child is more prone to iron deficiencies as they continue to grow. Iron deficiency can cause many problems later in life, including anemia. If nothing else is working for your child, ask your doctor if these formulas would be worth a try. But otherwise, we recommend steering clear, as studies have been showing the major negative effects of these products for several decades.

Procedures and Medical Intervention

Although somewhat controversial, other options do exist for babies with Gastroesophageal Reflux. Medical procedures to determine the root cause of discomfort are often, ironically, uncomfortable themselves. Many of these interventions are invasive as well as expensive. Medications may help certain infants, but many of these can be dangerous, and can cause a long list of side effects and other problems. Studies have provided conflicting results as to whether or not medications even help in aiding reflux symptoms in infants. Except in extreme cases, it is recommended to try other alternatives before taking this step, as most cases of reflux in infants dissipate on their own over time, as the child grows past infancy.

Other Tactics

Aside from choosing the right formula, it is equally important to employ other strategies to help ease your baby’s symptoms. There are many helpful sources to explore when seeking new ways to help with infant reflux. Keeping them in an upright position during feeding and for 20-30 minutes after is widely recommended. Feeding your infant smaller meals more frequently can help too, or with a doctor’s approval, thickening your baby’s formula with certain cereals can sometimes cause less irritation during the digestion process. This video demonstrates some important steps in helping your baby feel better during and after feeding.

Best Formula for Babies with Reflux (Review)

Enfamil Nutramigen Infant Formula with Enflora LGG

Nutramigen formula is hypoallergenic, meaning its proteins are broken down more extensively than the partially-hydrolyzed options. As mentioned earlier, in order for a brand to stamp “hypoallergenic” across its baby formula, it must first be passed through extensive testing to prove itself worthy of such a claim. This formula contains all of the regular nutrients of most baby formulas, but is also suitable for lactose intolerance. This makes for a great addition to the usual gentle formula, as it can reduce or alleviate any symptoms caused by lactose-intolerance or an allergy to milk proteins.

The fact that this formula is created with extensively hydrolyzed proteins, its taste may vary quite a bit from what your baby is used to. So, if your little one is a picky eater, it may be an issue, or something that could take some time to get used to.

It is also worth noting that some insurance companies will pay for baby formula, if it is considered a medical necessity. Enfamil has created a form, which can be found on their website, for you to bring to your pediatrician to fill out, and then send to your insurance provider to ask for reimbursement.


  • Hypoallergenic
  • Suitable for lactose intolerance
  • ​Sometimes used as a milk-substitute past the first 12 months
  • Iron-fortified
  • ​Contains DHA and ARA
  • Wide array of vitamins and nutrients
  • Contains LGG Probiotic


  • Contains corn syrup

Enfamil PREMIUM Gentlease, Milk-Based Formula

Enfamil is a widely-known brand in baby formulas. They offer many formulas for a wide variety of needs, two of which I have recommended here. The first is Gentlease. It’s a milk-based formula, although it is partially-hydrolyzed, meaning the milk proteins have been slightly broken down for easier digestion.


  • Contains DHA and ARA, commonly found in breast milk
  • Complex array of essential vitamins and nutrients
  • ​Proteins combined to emulate breast milk proteins
  • Iron-fortified


  • Contains dairy and soy (potential allergens)
  • Proteins only partially broken down, rather than fully-hydrolyzed
  • Contains corn syrup

Gerber Good Start Gentle Non-GMO Powder Infant Formula

Gerber is one of the top brands in infant formulas. Their Good Start line of products has a long list of options. I’ve chosen their Gentle formula as a recommendation due to the wider range of issues it can alleviate. As a side note, they do have two other products related to children with digestion issues: Gerber Good Start Gentle for Supplementing Breastfeeding, and Gerber Good Start Soothe. All three of these formulas are Non-GMO, meaning they contain no genetically modified ingredients, so if this is a particularly important factor to you and your family, Gerber Good Start Gentle could be a viable option.

Another great thing about the Gerber Good Start product line is that they offer a money back guarantee, for any single unit. So if you decide to give any of their formulas a shot, and find that it ends up not being the best option for your child's particular needs, you can contact Gerber, and they will issue you a refund!


  • Probiotic and Prebiotic
  • Contains DHA and ARA
  • ​Non-GMO
  • Iron-fortified
  • ​Wide array of vitamins and nutrients
  • Contains many Amino and Fatty Acids
  • Corn product is not the first ingredient


  • Does contain corn maltodextrin
  • Contains lactose and soy ingredients

Similac Sensitive Non-GMO Baby Formula

Similac Sensitive is another partially-hydrolyzed formula. It contains a specific blend of nutrients called “OptiGro” for healthy growth and brain function. One very important aspect to note is that Similac Sensitive contains nucleotides. Breast milk is usually very high in nucleotides, and studies have shown the essential role they provide in the growth and development of infants.


  • Contains nucleotides
  • Large array of essential vitamins and nutrients
  • ​Iron-fortified
  • Contains Similac’s “OptiGro” compound of DHA, Lutein, and Vitamin E for healthy growth


  • Contains milk and soy
  • Made with Corn Syrup
  • Claims to ease symptoms in lactose-sensitive infants, yet not entirely lactose-free

Parent's Choice Gentle Infant Formula

Parent’s Choice is another widely-known manufacturer of infant formulas. Their Gentle formula is, once again, partially-hydrolyzed, as well as Certified Kosher. The addition of prebiotics makes for an especially well rounded nutrient profile, which can aid in the production of intestinal bacteria which can promote healthy digestion. However, the lack of ingredient information on their website is both uncommon and seems a bit misleading, as the ingredients are the most important factor when it comes to formulas for infants with reflux.


  • Contains DHA and ARA
  • Iron-fortified
  • ​Contains Prebiotics
  • Certified Kosher


  • Milk-based formula (although proteins are partially hydrolyzed/broken down)
  • No listed ingredients on Parent’s Choice website


Although you may have to try several formulas until you find the right one for your child, it is clear which formula has the best profile for infants with reflux. Nutramigen with Enflora LGG is certified hypoallergenic, meaning it has gone through extensive testing, and the proteins are fully broken down for the easiest digestion.

With its long list of added benefits, Nutramigen with Enflora LGG will give your child all the necessary building blocks for healthy growth. Combined with healthy habits for babies with reflux, this formula can alleviate some or all of your infant’s spitting up, discomfort, and fuss… and a happy baby is a happy home!

Zoey Miller

Zoey is our baby equipment expert. Her topics are: baby, diapers, feeding, and pregnancy. She graduated from Teachers College, Columbia University and worked at nursery and kindergarten. Unfortunately she had some issues when she wanted a baby, but she eventually solved the problem and gained huge knowledge in this topic. She is a mother of 2 and her expertise has been accumulated from her nursery job and her own life with Naomi and Daisy. Linkedin